NR4A1 also regulates mTOR signaling in RMS and other cancer cell [27] lines and NR4A1 knockdown or antagonists inhibit mTOR through reactive oxygen species-dependent activation of AMPK (i.e.: pAMPK) [26, 35–37] and both kaempferol and quercetin induced pAMPK in Rh30 (Fig. 6A) and Rh41 (Fig. 6B) cells and this was accompanied by decreased phosphorylated mTOR and the downstream kinase p70S6K. The gene discussed is RPS6KB1; the disease is cancer.