NR4A1 and cancer: NR4A1 also regulates mTOR signaling in RMS and other cancer cell [27] lines and NR4A1 knockdown or antagonists inhibit mTOR through reactive oxygen species-dependent activation of AMPK (i.e.: pAMPK) [26, 35–37] and both kaempferol and quercetin induced pAMPK in Rh30 (Fig. 6A) and Rh41 (Fig. 6B) cells and this was accompanied by decreased phosphorylated mTOR and the downstream kinase p70S6K.