PI3K-AKT signaling pathway is involved in ovarian cancer (OV), uterine corpus endometrial carcinoma (UCEC), cervical cancer (CESC) [64], Renal Cell Carcinoma, Stomach adenocarcinoma (STAD) [65], colorectal cancer (COAD, READ) [66], breast cancer (BRCA) [67], lung cancer (LUSC, LUAD) [68], cholangiocarcinoma (CHOL) [69], prostate cancer (PRAD) [70], thyroid malignancies (THCA) [71], pancreatic cancer (READ) [72]. The gene discussed is AKT1; the disease is hereditary clear cell renal cell carcinoma.