TRB3 silencing reduced right ventricular systolic pressure (RVSP) (Fig. 7A, B) and relieved ventricular hypertrophy as indicated by the RV/(LV + S) ratio (Fig. 7C), and silencing TRB3 did not affect systemic blood pressure (Fig. 7D). Here, TRIB3 is linked to Ventricular hypertrophy.