CASP5 and nonpapillary renal cell carcinoma: After two independent datasets from the GEO database were utilized to externally illustrate the expression of these 11 genes in ccRCC, six pyroptosis-associated regulators (AIM2, CASP5, NLRP3, NOD2, GZMA, and GZMB) demonstrated to be highly expressed in ccRCC (Fig. 1B).