CD4 and leukemia: These data support the idea that IRAK1 expressing leukemia cells induce the accumulation of MDSCs, which concomitantly suppress CD4+/8+ T-cell mediated leukemia clearance, while knockout of IRAK1 leads to failure in MDSC induction and subsequent immune suppression, resulting in T cell mediated clearance of the IRAK1 null leukemia cells.