CD4 and leukemia: Immuno-phenotyping of PB cells in these mice showed decreases in GFP+ cells, as well as gMDSC and mMDSC, with increases in the CD4+ and CD8+ populations in the KO#25 cells compared with the MC engrafted mice (Fig. 7I-J), further confirming the role of IRAK1 activated IFN-γ from leukemia cells in induction of MDSCs during the establishment of immune evasion.