Before exploring the role of eIF4A1 and c-MYC in the regulatory effect in pancreatic cells, we analyzed eIF4A1 expression in the pancreatic cancer cell lines Panc-1, Capan-2, AsPC-1, and MiaPaca-2, and in the normal pancreatic ductal epithelial cell line HPDE. This evidence concerns the gene EIF4A1 and familial pancreatic carcinoma.