Combining u[TIMP-2]*[IGFBP7] with the clinical risk factor model further improved the AUCs to 0.797 (95%CI, 0.726-0.867) and 0.845 (95%CI, 0.780-0.910) as compared to clinical model alone both for predicting AKI progression or AKI progression with death. This evidence concerns the gene IGFBP7 and acute kidney injury.