TIMP2 and acute kidney injury: Renal cell cycle arrest biomarkers, urinary tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor binding protein-7 (IGFBP-7), have been shown to efficiently predict the risk of severe AKI development in ICU and were approved by U.S. FDA as a test of determining the risk of AKI development [6, 7].