TIMP2 and acute kidney injury: As shown in Supplemental Table S1, u[TIMP-2]*[IGFBP7], uKIM-1 and uIL-18 predicted the progression of AKI in sepsis, with u[TIMP-2]*[IGFBP7] presented the greatest AUC (0.745, 95%CI 0.667-0.823) as compared to uKIM-1 (AUC 0.719, 95%CI 0.638-0.800) and uIL-18 (AUC 0.619, 95%CI 0.525-0.713).