In this study, we observed that the 21 kDa fragment was also significantly increased in 3xTg mice (n = 5–6, p < 0.05) (Figure 1a,b) and in hippocampal samples from APP/PS1 mouse, another model of AD that is characterized by increased levels of Aβ (n = 4–7, p < 0.05) (Figure S1C, D). The gene discussed is APP; the disease is Alzheimer disease.