The cleavage pattern of LB1 was similar to that observed after Aβ42 toxicity in SH‐SY5Y (Figure 4a), primary rat hippocampal neurons (Figure 4d), and in 3xTg mouse hippocampal samples (Figure 1a) as well as in human AD brain tissue (Figure 3c). Here, CKAP2 is linked to Alzheimer disease.