Because overexpression of TM2D1 in a human neuroblastoma cell line (SH-SY5Y) increased the sensitivity of these cells to cell death caused by incubation with aggregated Aβ and since the DRF motif was found to be required for this activity, the authors of this original study proposed that TM2D1 may function as a transmembrane receptor that mediates Aβ-toxicity [24]. The gene discussed is TM2D1; the disease is neuroblastoma.