Our observations also raise the question of whether Dsg1 loss may be a common factor in PSO and other ichthyoses with Th17 skewing, as is the case in Netherton syndrome, in which Dsg1 is degraded due to loss of LEKTI-1 (lympho-epithelial kazal type related inhibitor type 5) function (45, 46). Here, DSG1 is linked to ichthyosis.