We also observed that NFκB1 and RELA target genes were associated with the downregulated genes in patients with PF (Figure 6C), suggesting that targeting Dsg1 by autoantibodies does not block its ability to downregulate NFκB activity, unlike genetic loss such as that observed in the Dsg1–/– mouse and SAM syndrome. This evidence concerns the gene DSG1 and pemphigus foliaceus.