Analysis of cadherin and cadherin-associated genes in PF patient samples revealed similarities to the Dsg1–/– mouse, including a significant increase in DSC1 gene expression, with differences including significant downregulation of DSG3 in patients with PF compared with its upregulation in Dsg1–/– skin (Figure 5E, Supplemental Figure 2, A and E, and Supplemental Figure 3G). The gene discussed is DSG3; the disease is pemphigus foliaceus.