Additional comparisons between the Dsg1–/– animals and SAM syndrome or PF revealed that 12.9% of the genes significantly upregulated in Dsg1–/– skin were also significantly upregulated in lesional skin from patients with SAM syndrome, and 11.7% of significantly downregulated genes in the Dsg1–/– skin were also significantly downregulated in patients with SAM syndrome (Figure 6, A, B, D, and F). Here, DSG1 is linked to pemphigus foliaceus.