Postprandial insulin clearance (i.e., the rate of removal of insulin from plasma) is a function of the amount of insulin delivered to organs that clear insulin, so people with obesity and insulin resistance have low postprandial insulin clearance because of high ISRs and postprandial plasma insulin concentrations, whereas people with obesity and T2D have “normal” ICRs because of defective ISRs and lower postprandial insulin concentrations. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.