INS and type 2 diabetes mellitus: Both the plasma insulin concentration AUC0–180 and the ISR AUC0–180 were highest in the 2 obese groups with IGT, with no differences between these 2 groups, and both the insulin concentration AUC0–180 and the ISR AUC0–180 were higher in the Ob-NFG-NGT and the Ob-T2D groups than in the lean group (Figure 1, B and C, and Supplemental Table 1).