The candidate genes following the early expression pattern were coexpressed with the DiGeorge syndrome–associated TBX1 (42, 43), whereas those with the late expression pattern were coexpressed with GATA4, NKX2-5, and TBX5 cardiac kernel transcription factors previously implicated in TOF (44–47). The gene discussed is TBX1; the disease is 22q11.2 deletion syndrome.