SLC7A5 and central nervous system cancer: Although Habermeier et al. showed a predominant 18F-FET accumulation via LAT1 in human LN229 glioblastoma cells [7] and Youland et al. reported LAT1 as a key determinant of 18F-DOPA accumulation in glioblastoma cell lines [4], the observed low staining intensity may indicate that LAT1 may not be the primary transporter in IDH-mutant WHO grade II and III gliomas [30].