Epigenetic alterations in multiple genes, including ROBO1, ROBO2, RPL22, TGFBR1 and TGFBR2, have been confirmed in iCCA; however, this is the first study to investigate epigenetic alterations in TET2 in iCCA [7]. Here, TGFBR1 is linked to infantile convulsions and choreoathetosis.