ADrosophila model of OPMD showed that alanine-expanded PABPN1increases cytoplasmic amounts of PABPN1 (53).These findings clarified the mechanisms of PABPN1 in modulating cytoplasmic mRNAstability during mouse early development, providing insights into the therapeuticpotential of OPMD. This evidence concerns the gene PABPN1 and oculopharyngeal muscular dystrophy.