To further support a role of RGN in suppressing apoptosis, overexpression of RGN in H4-II-E hepatoma cells was found to have a suppressive effect on cell death induced by sulforaphane by affecting the levels of pro- and anti-apoptotic factors such as Bax, cytochrome c and Bcl-2, that directly control mitochondrial mediated apoptosis via caspase 9 [32]. Here, CYCS is linked to hepatocellular carcinoma.