In most cases, METTL14 is identified as a tumor suppressor gene, which inhibits oncogenesis and progression of various cancers, such as bladder cancer,55 colorectal cancer,56, 57, 58 endometrial cancer,59, 60 gastric cancer,61, 62 glioblastoma,63 hepatocellular carcinoma,64, 65, 66 and renal cell carcinoma,52, 67, 68 by reducing m6A modification on key transcripts. This evidence concerns the gene METTL14 and hereditary clear cell renal cell carcinoma.