The observed reduction of inhibitory synapses in MS cases was not confounded by a global reduction in synapse coverage as assessed by synaptophysin (high inhibitory synaptic coverage: 0.514 ± 0.037 syn+/μm2 vs. low inhibitory synaptic coverage: 0.484 ± 0.012 syn+/μm2, p = 0.48). This evidence concerns the gene SYP and myeloid sarcoma.