In the current study, we extend these findings by demonstrating the extent of TMEM119+ resident microglial expression was reduced in HLA‐DRB1*15+ MS cases compared to HLA‐DRB1*15− MS cases, after correcting for age, sex, post‐mortem interval, and neuronal density (15+: 0.3833 ± 0.19 million pixels/mm2 vs. 15−: 0.6184 ± 0.49 million pixels/mm2, p = 0.031). Here, HLA-DRB1 is linked to myeloid sarcoma.