Non-COVID-19 patients had higher blood levels of leukocytes (8.9 [6–13.6] K/μl vs. 4.7 [± 2.31] K/μl; p = < 0.0001) and pro-BNP (318 [81.5–3247] pg/ml vs. 106 [50–404] pg/ml; p = 0.0211) when compared to COVID-19 patients. This evidence concerns the gene NPPB and COVID-19.