TCF12 and craniosynostosis: Lastly, patients with TCF12-related craniosynostosis had an increased SNB (p = 0.011), decreased ANB (p = 0.015), decreased NSL/NL (p = 0.026), increased SN/ML (p < 0.001), increased NL/ML (p = 0.001), and decreased NSL/BOP (p = 0.001) compared to controls (Table 5).