Furthermore, it is important to determine the severity of midface hypoplasia in these syndromes in order to determine the best timing of the start of orthodontic treatment and whether maxillofacial surgery is necessary in children with Muenke syndrome, Saethre-Chotzen syndrome, and TCF12-related craniosynostosis [17]. The gene discussed is TCF12; the disease is Saethre-Chotzen syndrome.