The extreme inflammation is usually evidenced by elevated serum of CRP, IL-6, and PCT which indicate the increasing of COVID-19 severity.27 High levels of CRP and procalcitonin in COVID-19 patients also associated with the progression of ARDS, myocardial injury, and death.27,28 The presence of secondary bacterial infection would be an additional explanation of this increase in inflammatory biomarkers. The gene discussed is IL6; the disease is bacterial infectious disease.