A study on the detection of hepatocyte death biomarkers in patients with hepatitis B virus-related ACLF (HBV-ACLF) finds that the serum HMGB1 level of HBV-ACLF patients is significantly higher than that of healthy controls and chronic hepatitis B (CHB) patients [30]. The gene discussed is HMGB1; the disease is chronic hepatitis B virus infection.