INS and type 1 diabetes mellitus: In another study by LW van Golen et al., the insulin Detemir and NPH on appetite-regulating brain areas responded to dietary stimulation for 12 weeks in type 1 diabetic patients were compared and found that there was less brain activity in bilateral insula areas in patients who received insulin Detemir compared with NPH which is due to inhibition of brain activity in bilateral insula as an appetite regulator area in response to food stimuli (22).