There may be several reasons for less weight gain in diabetic patients treated with detemir insulin, such as lower hypoglycemia (resulting in less eating to compensate for this complication), faster transfer of detemir from the blood-brain barrier (resulting in transmission of satiety signal to brain and inhibition of hepatic glucose production against peripheral glucose uptake) and increased adiponectin levels which is associated with weight loss and less eating (8-10). Here, INS is linked to Hypoglycemia.