Resent in-vitro works have shown that TSA increases the ratio between the levels of expression of anti-apoptotic (BCL-w and BCL-xl) and pro-apoptotic (BIM)genes in pancreatic cancer cell lines CFPAC1, Miapaca2, HPAF, PSN1, Panc1 PC, Paca44, RT45P1, and T3M4 (38). This evidence concerns the gene NT5C3A and familial pancreatic carcinoma.