Our previous work indicated that zebularine and TSA can inhibit DNMTs (DNMT1, DNMT3a, and DNMT3b), Class I HDACs (HDACs 1, 2, 3), and Class II HDACs (HDACs 4, 5, 6) and up-regulate CIP/KIP Family (p21Cip1/Waf1/Sdi1, p27Kip1, and p57Kip2) resulting in cell apoptosis in colon cancer LS 174T, and LS 180 cell lines (42, 43). The gene discussed is CDKN1A; the disease is colonic neoplasm.