The results of our study showed that APAP could significantly increase the damage degrees of centrilobular hypertrophy and granuloma in rat livers, and the levels of serum ALT and LDH in a dose-dependent manner, while pre-treatment of EGCG significantly decreased the elevation, demonstrating that EGCG is effective in alleviating hepatic injury caused by APAP. The gene discussed is GPT; the disease is Granuloma.