As a result, CKD caused a significant change in the AVPR2 protein in the nephrectomy group compared to the control group in rat kidney with experimental nephrectomy models, and the findings revealed that CKD caused by nephrectomy was strongly associated with polyuria and a vasopressin-resistant decreased expression of AQP2 [48], which was similar to our findings. This evidence concerns the gene AQP2 and chronic kidney disease.