Furthermore, cleavage of p100 into p52, an event triggered by the activation of a NIK (MAP3K14)-dependent non-canonical NF-κB response, was found starting at 4 h in normal esophageal fibroblasts and 2 h in active EoE fibroblasts following LIGHT treatment which was sustained for up to 24 h (Fig. 6d). The gene discussed is MAP3K14; the disease is eosinophilic esophagitis.