Furthermore, serum GPC-4 concentrations were related to renal insufficiency, bone development and correlate positively with systolic blood pressure (SBP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), fasting insulin and homeostasis model assessment for insulin resistance (HOMA-IR) score2,11. The gene discussed is GPC4; the disease is Renal insufficiency.