Similarly, the salivary levels of OSI, AGE, Aβ and IL-1β (sensitivity = 90.00%, specificity = 92.00%, p < 0.0001; sensitivity = 86.96%, specificity = 88.00%, p < 0.0001; sensitivity = 86.36%, specificity = 84.00%, p < 0.0001; sensitivity = 84.00%, specificity = 84.00%, p < 0.0001) significantly distinguished the patients with AD from the control patients (Table 6, Fig. 5). The gene discussed is IL1B; the disease is Alzheimer disease.