In the BM, Lin−;Sca-1+;c-Kit+ (LSK) and Lin−;Sca-1−;c-Kit+ (LK) cells were increased in AML WT mice compared to healthy controls, irrespective of their Gab2 genotype (Fig. 3A, Supplementary Fig. 3A, B). The gene discussed is KIT; the disease is acute myeloid leukemia.