Among the differentially expressed genes with a large log2 fold change, we found the RTK Axl and Gfra2, a co-receptor of the RTK Ret, to be significantly decreased in AML KO compared to AML WT BM (Fig. 6A), which was confirmed at protein level (Fig. 6B, C, Supplementary Fig. 5B, C). This evidence concerns the gene AXL and acute myeloid leukemia.