Given the growing number of reports linking AXL expression to TKI resistance in human AML [25–27] and as GAB2 confers TKI resistance in CML [11] and AML cell lines [14], we analyzed the TKI sensitivity of AML BM depending on the Gab2 genotype. The gene discussed is GAB2; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.