GRB2 and acute myeloid leukemia: In agreement with these observations and the documentation of a RET/GRB2/GAB2/PI3K/AKT/mTORC1 axis in neuronal cells [32], mTORC-related gene sets were downregulated in AML KO versus WT BM (i.e. HALLMARK_MTORC1_SIGNALING; statistical mean −1.89; q value 0.01 (gage)).