The latter lose their floxed Dnmt3a allele upon polyinosinic-polycytidylic acid (pIpC) induced Cre expression generating Flt3ITD/ITD/Dnmt3a−/+ animals, which will from hereon be referred to as AML mice, while Dnmt3af/+/Flt3ITD/ITD mice that do not express Cre and therefore retain their floxed Dnmt3a allele will be designated as MPN mice. The gene discussed is DNMT3A; the disease is acute myeloid leukemia.