SPAG5 and hepatocellular carcinoma: Moreover, our results showed that miR-1179 silencing with inhibitor in Huh7 and HepG2 HCC cells considerably upregulated SPAG5 expressions at both mRNA (Fig. 3I) and protein (Fig. 3J) levels, while miR-1179 overexpression with mimics in Huh7 and HepG2 HCC cells considerably downregulated SPAG5 expressions at both mRNA (Fig. 3I) and protein (Fig. 3J) levels.