It has also been pointed out that miR-1179 can target the E2F5 gene in regulating pancreatic cancer cell proliferation, thereby inhibiting tumor cell migration and invasion25; plays an important role in regulating the proliferation of glioblastoma cells by directly targeting E2F transcription factor 526; and plays important role in cancer through Akt signaling27,28. Here, E2F5 is linked to familial pancreatic carcinoma.