SPAG5 and hepatocellular carcinoma: Our luciferase reporter assay showed that miR-1179 could directly bind to circFOXM1 and SPAG5; miR-1179 inhibitor or SPAG5 overexpression reversed circFOXM1 siRNA-mediated inhibitory effect on HCC cell proliferation, migration and invasion abilities; and miR-1179 mimics or SPAG5 silencing reversed pLCDH-circFOXM1-mediated promotion on HCC cell proliferation, migration and invasion abilities.