The hallmark of hypoxia, HIF-1α, which is hydroxylated under the normoxic condition with O2 as a substrate and subsequently ubiquitinated for proteasomal degradation, accumulates under hypoxia and functions as a transcription factor to regulate target gene levels, exerting pleiotropic effects on cancer pathobiology, including angiogenesis, metabolism reprogramming, EMT, motility, stemness properties and immune evasion [16]. Here, HIF1A is linked to cancer.