In addition, transcriptional cofactors (27), including CREBBP (28), EP300 (28), XPO1 (CRM1; ref. 29), and KMT2A (23, 30) or WDR–SET1–COMPASS complexes (23, 30), interact with NUP98's IDR and mediate the transcriptional signature unique to NUP98-rearranged hematologic malignancies (22). This evidence concerns the gene XPO1 and hematologic disorder.