PRRX1 and acute leukemia: We next tested whether additional NUP98 FOs associated with acute leukemia formed liquid-like condensates in HEK293T cells and lin− HSPCs (Fig. 7A), including one displaying an alternative DNA-binding homeodomain (NUP98–PRRX1; ref. 47), another with an epigenetic mark–binding PHD domain (NUP98–KDM5A; ref. 21), and a third displaying a histidine and arginine (H/R)–rich region of unknown structure and function (NUP98–LNP1; ref. 48).