In keeping with the hypothesis that we can identify druggable vulnerabilities useful for the treatment of CDS by revealing genes specifically upregulated in CDS versus Ewing sarcoma, we checked the expression of mRNA and proteins in the HMGA2/IGF2BPs/IGF2 axis in CDS and Ewing sarcoma PDX-derived cell lines. The gene discussed is HMGA2; the disease is Ewing sarcoma.