Because previous work found that HMGAs are modulated after transducing mesenchymal cells with human CIC-DUX4 (9, 12), and that both HGMAs and IGF2BPs are specifically expressed in CIC-fused compared with other fusion-driven sarcomas (34), we focused further analysis on the relationship that links HMGAs to IGF2BP2/IGF2BP3 and to IGF2. The gene discussed is IGF2BP3; the disease is sarcoma.