CES1 and Stroke: A rare variant in CES1 (rs71647871, n=249 CT heterozygotes) with moderate clinical annotation evidence for clopidogrel on the PharmGKB database12 was not significantly associated with strokes or MIs (stroke HR 0.86, 95% CI 0.27 to 2.70, p=0.79; MI HR 1.26, 95% CI 0.99 to 1.60, p=0.057), although the MI association was borderline.