Given the widespread continuing use of clopidogrel, and the current scarcity of evidence on clinical outcomes due to the LoF variants in the primary care setting, we aimed to estimate the association between CYP2C19 LoF alleles and incident hospital-diagnosed ischaemic stroke and myocardial infarction (MI) in UK Biobank participants on treatment with clopidogrel. This evidence concerns the gene CYP2C19 and ischemic stroke.