Disruption of lung iron homeostasis appears to be involved in several lung diseases and we therefore looked for evidence of ferritinophagy, which describes a form of selective autophagy characterised by degradation of intracellular ferritin mediated by nuclear receptor coactivator 4 (NCOA4), which increases intracellular iron levels leading to accumulation of lipid ROS and ultimately cell death [52]. The gene discussed is NCOA4; the disease is lung disorder.