A cluster of 13 CpG loci (11 genes) were identified that displayed differential methylation in colon adenocarcinoma (COAD) (N = 289) compared to normal colon tissues (N = 38): ZNF671, TWIST1 (two CpG loci), TMEFF2, TM6SF1, GAS7, MAL, HIN1 (two CpG loci; SCGB3A1), COL6A2, AKR1B1, GPX7, ARHGEF7) (Fig. 1). This evidence concerns the gene AKR1B1 and colon adenocarcinoma.