Immunization of mice using several HCV epitopes (encoding; core132–142 [C], E2405–414 [E4], E2614–622 [E6] and NS31406–1415 [N] CD8+ CTL epitopes as CE4E6N polytope) and its HBsAg-fused counterpart elicited strong CTLs and IFN-γ-secreting cells that were further augmented towards a Th1 response and partial tumor protection by DNA-prime/peptide-boosting regimen compared to the adjuvant-formulated synthetic-peptide immunization. The gene discussed is IFNG; the disease is neoplasm.