To investigate the potential role of MCPIP1 in the development of skin carcinoma, we utilized a multistage chemical carcinogenesis approach to model the development of SCC in mouse skin with loss of keratinocyte MCPIP1 function (Krt14CreMcpip1fl/fl mice, herein referred to as Mcpip1eKO mice). The gene discussed is ZC3H12A; the disease is skin carcinoma.