Other three hyperdynamic CpGs common across four samples, as well as that in ISM1, were reported as EWAS markers of several traits of air-pollution (PM 2.5) [26], rheumatoid arthritis [27], infertility (studies on sperm) [28, 29, 31], exercise [32], and Kabuki syndrome [33]. Here, ISM1 is linked to rheumatoid arthritis.