Capizzi et al. provided the first evidence showing that the transversal wrist internal bone tissue area determined by nuclear magnetic resonance, but not wrist circumference, was associated with fasting plasma insulin levels and insulin resistance in overweight/obese children and adolescents, suggesting the area of the wrist bone, and not wrist fat component as the main contributor to the relationship between wrist circumference and insulin resistance in children and adolescents [41]. Here, INS is linked to Insulin resistance.