Dnaja3 protein was upregulated in the hippocampi of Alzheimer’s disease (AD) patients and the AD mouse model, and Dnaja3 induced amyloid β42 (Aβ42) production and neuronal apoptosis, which played a crucial role in the pathogenesis of AD [48, 49]. This evidence concerns the gene DNAJA3 and early-onset autosomal dominant Alzheimer disease.