CD274 and glioblastoma: High expression of PD-L1 in tumor-infiltrating lymphocytes is considered a good independent prognostic factor for patients with GBM (HR, 0.4; 95% CI, 0.2–0.8; P = 0.016), which is inconsistent with the prognostic significance of high expression of PD-L1 in GBM tumor cells [51].