While STING levels were reduced in TB40/E-infected fibroblasts compared to a mock infection (Fig. 8D), there was little difference in STING levels between fibroblasts infected with a virus encoding a UL138 allele with an added carboxy-terminal 3× FLAG epitope (TB40/E-green fluorescent protein [GFP]-UL138-FLAG) and one encoding an untagged UL138 allele with an inserted stop codon at position 16 (TB40/E-GFP-UL138-M16stop) (Fig. 8C and D). The gene discussed is STING1; the disease is infection.