Furthermore, HCMV infection leads to cytoplasmic relocalization of SAMHD1 (119), interferes with the interferon-dependent transcription of SAMHD1 at early times of infection (117) and induces Cullin-Ring E3 ligase-dependent degradation of SAMHD1 protein at late times of infection (117, 120). Here, SAMHD1 is linked to infection.