We performed the infection experiments with rD6/2-2g and rD6/2-2g-NSP1-null at different time points, and these data were repeated in two independent experiments (Fig. S2); thus, the reversion observed in rD6/2-2g-NSP1-null-inoculated mice is unlikely to be due to the contamination by rD6/2-2g. Here, SH2D3A is linked to infection.