SH2D3A and infection: With similar protein levels of RV VP6, indicating comparable replication between rD6/2-2g and rD6/2-2g-NSP1-null, the protein levels of IRF3 were undetectable in rD6/2-2g-infected MA104 cells whereas IRF3 was not degraded by rD6/2-2g-NSP1-null infection (Fig. 1D).