Furthermore, using different genomic association approaches, we found that common variants at the TAGLN locus and genetically predicted expression of TAGLN are both associated with elevations in plasma total and LDL-C and TGs, as well as with lipid-related phenotypes, such as body mass index, waist circumference, body fat percentage, dyslipidemia, and lipid-lowering medication use. This evidence concerns the gene TAGLN and metabolic syndrome.