Increased RCB score was significantly associated with worse event-free survival within all four breast cancer subtypes, with the HR associated with one unit increase in RCB score ranging from 1·55 (1·41–1·71) in the hormone receptor-positive, HER2-negative group to 2·16 (1·79–2·61) in the hormone receptor-negative, HER2-positive group (p<0·0001 for all subtypes; appendix pp 4–6). This evidence concerns the gene NR4A1 and breast cancer.