Increasing RCB was associated with a near-linear increase in log relative hazard rate among all breast cancer subtypes, except for the hormone receptor-positive, HER2-negative subtype, in which the log relative hazard rate remained near zero until an RCB score of around 1·5, close to the class threshold between RCB-1 and RCB-2 (figure 3; appendix p 11). The gene discussed is NR4A1; the disease is breast carcinoma.