GPT and injury: Because hypocapnia is a feature of severe Gram-negative septic shock (23), the two rabbits, denoted c-IgG(1) and c-IgG(5), with this preterminal condition also developed multiple organ dysfunction, as evidenced by >2-fold increases from preinfection baseline in levels of creatinine (a marker of acute kidney injury), amylase (a marker of acute pancreatic injury), and/or alanine aminotransferase (a marker of acute liver injury) (see Fig. S2).