IL6 and polyarticular arthritis: We found that DNase II−/−STINGS365A/S365A mice, but not DNase II−/−STINGΔCTT/ΔCTT or DNase II−/−STINGL373A/L373A mice, developed polyarthritis characterized by inflammation and bone erosion due to the production of inflammatory cytokines such as TNF-α and IL-6.