Loss-of-function mutations of the TREX1 gene caused autoinflammatory diseases such as Aicardi-Goutières syndrome and familial chilblain lupus (Crow et al., 2006; Rice et al., 2015; Richards et al., 2007; Tüngler et al., 2012). This evidence concerns the gene TREX1 and Aicardi-Goutieres syndrome.