TLR7 and Splenomegaly: However, 10-mo-old DNase II−/−Ifnar1−/− mice have been reported to develop splenomegaly and produce antinuclear antibodies in a STING- or AIM2-independent manner; instead, Unc93b, which regulates the localization of several TLRs (e.g., TLR3, TLR7, and TLR9) to the endosome, is required (Baum et al., 2015; Pawaria et al., 2015).